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KMID : 0620720160220030220
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Natural Product Sciences
2016 Volume.22 No. 3 p.220 ~ p.224
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Anti-Helicobacter pylori Compounds from Polygonum cuspidatum
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Atif Ali Khan Khalil
Park Woo-Sung
Kim Hye-Jin
Kazi Marjahan Akter
Ahn Mi-Jeong
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Abstract
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Anti-Helicobacter pylori activity guided fractionation led to the isolation of five anthraquinones, two stilbenes and one naphthoquinone from the EtOAc fraction of Polygonum cuspidatum, using silica gel column chromatography, Sephadex-LH20, MPLC and recrystallization. The chemical structures were identified to be physcion (1), emodin (2), anthraglycoside B (3), trans-resveratrol (4), anthraglycoside A (5), polydatin (6), 2- methoxy-6-acetyl-7-methyljuglone (7) and citreorosein (8) by UV, ¹H-NMR, ¹³C-NMR and mass spectrometry. Anti-Helicobacter pylori activity including MIC values of each compound was evaluated. All of the isolates exhibited anti-H. pylori activity of which MIC values were lower than that of a positive control, quercetin. Compounds 2 and 7 showed potent growth inhibitory activity. Especially, a naphthoquinone, compound 7 displayed most potent antibacterial activity with MIC50 value of 0.30 μM and MIC90 value of 0.39 μM. Although anti-H. pylori activity of this plant was previously reported, this is the first report on that of compounds isolated from this species. From these findings, P. cuspidatum roots or its isolates may be useful for H. pylori infection and further study is needed to elucidate mechanism of action.
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KEYWORD
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Polygonum cuspidatum, Anti-Helicobacter pylori activity, Emodin, 2-Methoxy-6-acetyl-7-methyljuglone
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