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KMID : 0620720170230020113
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Natural Product Sciences
2017 Volume.23 No. 2 p.113 ~ p.118
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Integracide K: A New Tetracyclic Triterpenoid from Desmodium uncinatum (Jacq.) DC. (Fabaceae)
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Tsafack Borice Tapondjou
Ponou Beaudelaire Kemvoufo
Teponno Remy Bertrand
Nono Raymond Ngansop
Jenett-Siems Kristina
Melzig Matthias F.
Park Hee-Juhn
Tapondjou Leon Azefack
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Abstract
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A new tetracyclic triterpenoid [4,4,24-trimethylcholesta-Δ8,9;14,15;24,28-trien-3β,11β,12α-triol-12-acetate, 3-sulfate] sodium salt (1), together with eight known compounds including ergosterol 5α,8α-endoperoxide (2), 1,9-dihydroxy-3-methoxy-2-methylpterocarpan (3), 3-O-β-D-2-acetyl-amino-2-deoxyglucopyranoxyloleanoic acid (4), hydnocarpin (5), derrone (6), isovitexin (7), erythrinin C (8), and 5,4`-dihydroxy-2``-hydroxyisopropyldihydrofurano [4,5:7,8]-isoflavone (9), were isolated from the EtOAc soluble fraction of the methanol extract of aerial part of Desmodium uncinatum collected in the western highland of Cameroon. The structures of these compounds were established by comprehensive interpretation of their spectral data mainly including 1D- (1H and 13C), 2D-NMR (1H-1H COSY, HMQC, HMBC) spectroscopic and ESI-TOF-MS mass spectrometric analysis. The isolation of an integracide-like compound from plant origin is a very unusual finding.
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KEYWORD
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Desmodium uncinatum, Fabaceae, Tetracyclic triterpenoid, Integracide, Isoflavonoids
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