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KMID : 0620720170230020132
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Natural Product Sciences
2017 Volume.23 No. 2 p.132 ~ p.138
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Synergetic Hepatoprotective Effects of Korean Red Ginseng and Pueraria Radix on the Liver Damaged-Induced by Carbon Tetrachloride (CCl4) in Mice
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Hwang Seung-Hwan
Wang Zhiqiang
Kang Il-Jun
Lim Soon-Sung
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Abstract
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This study was designed to investigate the synergetic hepatoprotective effects from a mixture of Korean Red Ginseng and Pueraria Radix on carbon tetrachloride (CCl4)-induced hepatotoxicity in mice. Liver toxicity was induced by intraperitoneal administration of CCl4 (0.6 mg/kg) in 12 groups of ICR mice. The negative control group was given CCl4 without test samples and the normal group was given no treatment. Among treatment groups, the RGAP treatment (Korean Red ginseng acetic acid extract : Pueraria radix water extract, w/w, 38.4:57.6) decreased CCl4-elevated ALT (101.60 IU/L), AST (833.89 IU/L), and LDH (365.02 IU/L) levels in the serum, and increased the SOD (11.03 unit/mg protein) and CAT (0.37 unit/mg protein) levels and the LPO levels (59.09 μM/g tissue) more than that in the mice group with CCl4-induced control group hepatotoxicity. These results suggest that administration of a mixture of Korean Red ginseng and Pueraria radix decreases CCl4-induced liver damage and enhances antioxidant activity in mice and imply that administration of the mixture in a certain ratio is more effective than single administration of either Korean Red ginseng or Pueraria radix alone.
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KEYWORD
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Carbon tetrachloride, Red Ginseng, Pueraria Radix, Hepatoprotective, Synergetic
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