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KMID : 0620720170230030208
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Natural Product Sciences
2017 Volume.23 No. 3 p.208 ~ p.212
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Sesquiterpenoids from the heartwood of Juniperu s chinensis
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Jung Hee-Jin
Min Byung-Sun
Jung Hyun-Ah
Choi Jae-Sue
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Abstract
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A new sesquiterpenoid, 11-hydroxy-valenc-1(10),3(4)-dien-2-one (3), two chemically synthesized but first isolate from nature, 3-oxocedran-8β-ol (1) and valenc-1(10),3(4),11(12)-trien-2-one (2) along with four known compounds, sugiol (4), (+)-nootkatone (5), 11-hydroxy-valenc-1(10)-en-2-one (6), and clovandiol (7), were isolated from the heartwood of Juniperus chinensis. All chemical structures were elucidated using extensive spectroscopic analysis including 1D and 2D NMR spectroscopy. Valenc-1(10),3(4),11(12)-trien-2-one (2) exhibited significant inhibitory activity against butyrylcholinesterase with an IC50 value of 68.45 μM.
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KEYWORD
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Juniperus chinensis, 3-Oxocedran-8β-ol, Valenc-1(10), 3(4), 11(12)-trien-2-one, 11-Hydroxy-valenc-1(10), 3(4)-dien-2-one, Acetylcholinesterase, Butyrylcholinesterase
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