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KMID : 0620720170230040291
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Natural Product Sciences
2017 Volume.23 No. 4 p.291 ~ p.298
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Cytotoxicity and Structure Activity Relationship of Dammarane-Type Triterpenoids from the Bark of Aglaia elliptica against P-388 Murine Leukemia Cells
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Hidayat Ace Tatang
Farabi Kindi
Harnet Desi
Maharani Rani
Darwat
Nurlelasari
Mayanti Tri
Setiawan Arlette Suzy
Supratman Unang
Shiono Yoshihito
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Abstract
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Six dammarane-type triterpenoids, dammar-24-en-3β-ol (1), 3β-epicabraleahydroxy lactone (2), (E)-25-hydroperoxydammar-23-en-3β,20-diol (3), dammar-24-en-3β,20-diol (4), 3β-acetyl-20S,24S-epoxy-25-hydroxydammarane (5), and 3β-epiocotillol (6) were isolated from the methanolic extract of the bark of Aglaia elliptica. The chemical structure were identified on the basis of spectroscopic evidence and by comparison with those spectra previously reported. Compounds 1 - 6 were isolated first time from this plant. Compounds 1 - 6, along with a known synthetic analog, cabraleone (7) were evaluated their cytotoxic activity against P-388 murine leukimia cells in vitro. Among those compounds 3β-acetyl-20S,24S-epoxy-25-hydroxydammarane (5) showed strongest cytotoxic activity with IC50 value of 8.02 ± 0.06 μM.
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KEYWORD
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Dammarane-type Triterpenoids, Aglaia elliptica, Meliaceae, P-388 murine leukimia cell
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