|
KMID : 0620720180240010047
|
|
Natural Product Sciences
2018 Volume.24 No. 1 p.47 ~ p.53
|
|
|
A Conformational Isomer of Soulattrolide from the Stem Bark of Calophyllum symingtonianum and Its Antibacterial Activity
|
|
Susanti Deny
Attoumani Nissad
Taher Muhammad
Rezali Mohd Fazlin
Sohrab Md. Hossain
Hasan Choudhury Mahmood
Zakaria Zainul Amiruddin
|
|
|
Abstract
|
|
|
|
Callophylum symingtonianum (Guttiferae), an evergreen broad-leaved tree that usually grows in hill forests, can be found distributed in the Malay Peninsula. The barks, leaves, flowers and seeds is often used medicinally to treat diarrhea and rheumatism. In the present study, we isolated two inophyllum type coumarins, 12-O-ethylinophyllum D (1) and iso-soulattrolide (2) from the stembarks of C. symingtonianum together with their antibacterial activity. The compounds were isolated by chromatographic methods on a silica gel. The structures were established by spectroscopic methods including UV, IR, (1D and 2D) NMR and mass spectrometry as well as by comparison with several literature sources. The antibacterial activity of those compounds was tested using a disc-diffusion assay against Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa. Both compound exhibited mild inhibition against P. aeruginosa with both 111 μg/ml MIC value. Compound 2 also inhibits S. aureus with 25 μg/ml MIC value.
|
|
|
KEYWORD
|
|
|
Calophyllum symingtonianum, Guttiferae, Coumarins, Antibacterial
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|