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KMID : 0620720180240020088
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Natural Product Sciences
2018 Volume.24 No. 2 p.88 ~ p.92
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Garcinexanthone G, a Selective Butyrylcholinesterase Inhibitor from the Stem Bark of Garcinia atroviridis
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Khaw Kooi-Yeong
Murugaiyah Vikneswaran
Khairuddean Melati
Tan Wen-Nee
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Abstract
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The present study was undertaken to investigate the isolated compounds from the stem bark of Garcinia atroviridis as potential cholinesterase inhibitors and the ligand-enzyme interactions of selected bioactive compounds in silico. The in vitro cholinesterase results showed that quercetin (3) was the most active AChE inhibitor (12.65 ± 1.57 μg/ml) while garcinexanthone G (6) was the most active BChE inhibitor (18.86 ± 2.41 μg/ml). It is noteworthy to note that compound 6 was a selective inhibitor with the selectivity index of 11.82. Molecular insight from docking interaction further substantiate that orientation of compound 6 in the catalytic site which enhanced its binding affinity as compared to other xanthones. The nature of protein-ligand interactions of compound 6 is mainly hydrogen bonding, and the hydroxyl group of compound 6 at C-10 is vital in BChE inhibition activity. Therefore, compound 6 is a notable lead for further drug design and development of BChE selective inhibitor.
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KEYWORD
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Garcinia atroviridis, Garcinexanthone G, Butyrylcholinesterase, Molecular docking
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