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KMID : 0620720180240020099
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Natural Product Sciences
2018 Volume.24 No. 2 p.99 ~ p.102
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Ameliorative Effects of Ombuoside on Dopamine Biosynthesis in PC12 Cells
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Davaasambuu Uchralsaikhan
Park Keun-Hong
Park Hyun-Jin
Choi Hyun-Sook
Lee Chong-Kil
Hwang Bang-Yeon
Lee Myung-Koo
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Abstract
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This study investigated the effects of ombuoside, a flavonol glycoside, on dopamine biosynthesis in PC12 cells. Ombuoside at concentrations of 1, 5, and 10 μM increased intracellular dopamine levels at 1 - 24 h. Ombuoside (1, 5, and 10 μM) also significantly increased the phosphorylation of tyrosine hydroxylase (TH) (Ser40) and cyclic AMP-response element binding protein (CREB) (Ser133) at 0.5 - 6 h. In addition, ombuoside (1, 5, and 10 μM) combined with L-DOPA (20, 100, and 200 μM) further increased intracellular dopamine levels for 24 h compared to L-DOPA alone. These results suggest that ombuoside regulates dopamine biosynthesis by modulating TH and CREB activation in PC12 cells.
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KEYWORD
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Ombuoside, Dopamine biosynthesis, TH, CREB, PC12 cells
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