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KMID : 0620720180240030159
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Natural Product Sciences
2018 Volume.24 No. 3 p.159 ~ p.163
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Chinoketides A and B, Two New Antimicrobial Polyketides from the Endophytes of Distylium chinense with the “Black-Box” Co-culture Method
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Lv Meng-Meng
Tan Ming-Hui
Lu Li-Wen
Zhang Rong-Hua
Guo Zhi-Yong
Liu Cheng-Xiong
Yang Jin
Zou Kun
Proksch Peter
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Abstract
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Two new polyketides, chinoketides A and B (1 - 2) with a known compound xylarphthalide A (3), were isolated from the solid medium of the endophytes from the leaves of the relic plant Distylium chinense with the “black-box” co-culture method, and the structures of two new compounds were elucidated by NMR, MS and CD spectra. And the absolute configurations of chinoketides A (1) and B (2) were determined as 2R,3R,8S and 5R,6S by calculating their ECD spectra to compare with the experimental CD spectra. Finally, the antimicrobial activities were evaluated to Erwinia carotovora sub sp. Carotovora (Jones) Bersey et al, and the results showed that compounds 1 - 3 displayed the antimicrobial activities with MIC value at 20.5, 30.4 and 10.2 μg/mL.
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KEYWORD
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Polyketides, “Black-box” Co-culture, Distylium chinense, Antimicrobial activity, Structural elucidation
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