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KMID : 0620720180240030194
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Natural Product Sciences
2018 Volume.24 No. 3 p.194 ~ p.198
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Chemicals from Cimicifuga dahurica and Their Inhibitory Effects on Pro-inflammatory Cytokine Production by LPS-stimulated Bone Marrow-derived Dendritic Cells
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Thao Nguyen Phuong
Lee Young-Suk
Luyen Bui Thi Thuy
Oanh Ha Van
Ali Irshad
Arooj Madeeha
Koh Young-Sang
Yang Seo-Young
Kim Young-Ho
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Abstract
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Inflammation is a biological response caused by overactivation of the immune system and is controlled by immune cells via a variety of cytokines. The overproduction of pro-inflammatory cytokines enhances abnormal host immunity, resulting in diseases such as rheumatoid arthritis, cardiovascular disease, Alzheimer’s disease, and cancer. Inhibiting the production of pro-inflammatory cytokines such as interleukin (IL)-12p40, IL-6, and tumor necrosis factor (TNF)-α might be one way to treat these conditions. Here, we investigated the anti-inflammatory activity of compounds isolated from Cimicifuga dahurica (Turcz.) Maxim., which is traditionally used as an antipyretic and analgesic in Korea. In primary cell culture assays, 12 compounds were found to inhibit the production of pro-inflammatory cytokines (IL-12p40, IL-6, and TNF-α) in vitro in bone marrow-derived dendritic cells stimulated with LPS.
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KEYWORD
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Cimicifuga dahurica, Ranunculaceae, Anti-inflammatory, IL-12 p40, IL-6, TNF-α
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