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KMID : 0620720190250010076
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Natural Product Sciences
2019 Volume.25 No. 1 p.76 ~ p.80
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Nitric Oxide Inhibitory Constituents from the Fruits of Amomum tsao-ko
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Kim Jun-Gu
Le Thi Phuong Linh
Hong Hye-Ryeong
Han Jae-Sang
Ko Jun-Hwi
Lee Seung-Hyun
Lee Mi-Kyeong
Hwang Bang-Yeon
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Abstract
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Bioactivity-guided fractionation of MeOH extract of the dried fruits of Amomum tsao-ko led to isolation of nine compounds (1 ? 9). Their structures were elucidated by spectroscopic methods including extensive 1D and 2D-NMR, as alpinetin (1), naringenin-5-O-methyl ether (2), naringenin (3), hesperetin (4), 2′,4′,6′-trihydroxy-4-methoxy chalcone (5), tsaokoin (6), boesenbergin B (7), 4-hydroxyboesenbergin B (8), and tsaokoarylone (9). Of these, compound 8 was isolated from a natural source for the first time, which was previously reported as a synthetic product. The isolated compounds (1 ? 9) were tested for their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages. Among them, three chalcone derivatives (compounds 5,7, and 8) and a diarylheptanoid (compound 9) exhibited significant inhibitory activity on the NO production with IC50 values ranging from 10.9 to 22.5 μM.
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KEYWORD
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Amomum tsao-ko, Zingiberaceae, Nitric oxide, Anti-inflammatory activity
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