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KMID : 0620720190250020130
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Natural Product Sciences
2019 Volume.25 No. 2 p.130 ~ p.135
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Chemical Constituents of Impatiens balsamina Stems and Their Biological Activities
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Kim Dong-Hyun
Lee Tae-Hyun
Subedi Lalita
Kim Sun-Yeou
Lee Kang-Ro
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Abstract
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The purification of the MeOH extract from Impatiens basamina by repeated column chromatography led to the isolation of one new tetrahydronaphthalene (1), together with eleven known compounds (2 - 12). The structure of the new compound (1) was determined by spectral data analysis (1H and 13C-NMR, 1H-1H COSY, HSQC, HMBC, NOESY, and HR-ESI-MS). Isolated compounds (1 - 12) were evaluated for their inhibitory effects on NO production in LPS-activated murine microglial BV-2 cells and their effects on NGF secretion from C6 glioma cells. Compounds 3, 7, and 10 reduced NO levels in LPS-activated murine microglial cells with IC50 values of 26.89, 25.59, and 44.21 μM, respectively. Compounds 1, 5, and 9 upregulated NGF secretion to 153.09 ± 4.66, 156.88 ± 8.86, and 157.34 ± 3.30%, respectively.
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KEYWORD
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Impatiens balsamina, balsaminaceae, tetrahydronaphthalene, neuroprotective effect
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