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KMID : 0620720190250020165
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Natural Product Sciences
2019 Volume.25 No. 2 p.165 ~ p.171
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Identification of a Novel Function of Extract of Gingko biloba (EGb 761®) as a Regulator of PYY Secretion and FFA4 Activation
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Kim Hye-Young
Kim Kyong
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Abstract
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Although the functions of a standardized extract of Gingko biloba leaves (EGb 761®) has been reported with regard to neurobiological properties, no attention has been paid to the impact of EGb 761® on the neuronal regulation of energy homeostasis. To evaluate the hypothesis that EGb 761® affect the secretion of peptide tyrosine tyrosine (PYY) and the activation of free fatty acid receptor 4 (FFA4), which are involved in the neuronal circuitries that control energy homeostasis by inducing the transfer of information about the influx of energy to the brain, we examined whether EGb 761® can stimulate PYY secretion in the enteroendocrine NCIH716 cells and if EGb 761® can activate FFA4 in FFA4-expressing cells. In NCI-H716 cells, EGb 761® stimulated PYY secretion and the EGb 761®-induced PYY secretion was involved in the increase in intracellular Ca2+ concentration and the activation of FFA4. Furthermore, in FFA4-expressing cells, EGb 761® activated FFA4. These results suggest that EGb 761® may affect the control of energy homeostasis via the regulation of PYY secretion and FFA4 activation.
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KEYWORD
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EGb 761®, Peptide tyrosine tyrosine, Free fatty acid receptor 4, NCI-H716 cells
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