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KMID : 0620720190250030233
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Natural Product Sciences
2019 Volume.25 No. 3 p.233 ~ p.237
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Diels-Alder Type Adducts from Hairy Root Cultures of Morus macroura
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Happyana Nizar
Hakim Euis H.
Syah Yana M.
Kayser Oliver
Juliawaty Lia D.
Mujahidin Didin
Ermayanti Tri M.
Achmad Sjamsul A.
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Abstract
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Three Diels-Alder type adducts, guangsangon E (1), chalcomoracin (2) and sorocein I (3) were isolated from hairy root cultures of Morus macroura. The structures of the isolated compounds (1 - 3) were determined by spectroscopic method (NMR and MS), and spectral comparison to literature. Cytotoxic activities of the isolated compounds (1 - 3) were investigated against P-388 murine leukemia cell line. Guangsangon E (1) showed the most potent cytotoxicity against P-388 murine leukemia cell line with IC50 value of 2.75 ± 0.32 μg/ mL. To the best of our knowledge, guangsangon E (1) and sorocein I (3) were reported for the first time from the tissue cultures of M. macroura.
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KEYWORD
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Diels-Alder type adduct, Morus macroura, tissue cultures, cytotoxicity
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