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KMID : 0620720190250040304
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Natural Product Sciences
2019 Volume.25 No. 4 p.304 ~ p.310
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Anti-arthritic Effects of Oplopanax elatus in a Rat Model of Rheumatoid Arthritis (Adjuvant-induced Arthritis)
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Kwon Ki-Sun
Lim Hyun
Kwon Yong-Soo
Choi Hye-Ri
Kim Myong-Jo
Yoo Ji-Hye
Yoo Nam-Ho
Kim Hyun-Pyo
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Abstract
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The stems of Oplopanax elatus (OE) have long been used to treat inflammatory disorders in herbal medicine, and in the previous investigation, OE was found to possess anti-inflammatory activity in lipopolysaccharide-treated macrophages, RAW 264.7 cell. OE reduces inducible nitric oxide (NO) synthase-induced NO production, and interferes with mitogen-activated protein kinase activation pathways. In the present study, the pharmacological action of the water extract of OE was examined to establish anti-arthritic action, using a rat model of adjuvant-induced arthritis (AIA). The water extract of OE administered orally inhibited AIAinduced arthritis at (100 - 300) mg/kg/day. The paw edema was significantly decreased, in combination with reduced production of pro-inflammatory cytokines. The action mechanism includes an inhibition of MAPKs/ nuclear transcription factor-κB activation. These new findings strongly suggest that OE possesses anti-arthritic action, and may be used as a therapeutic agent in inflammation-related disorders, particularly in arthritic condition.
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KEYWORD
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Oplopanax elatus, rheumatoid arthritis, adjuvant-induced arthritis, mitogen-activated protein kinase
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