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KMID : 0620720200260010079
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Natural Product Sciences
2020 Volume.26 No. 1 p.79 ~ p.82
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A New Cinnamyl Acid Derivative from the Roots of Willughbeia coriacea Wall
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Tanjung Mulyadi
Tjahjandarie Tjitjik Srie
Saputri Ratih Dewi
Harsono Andre
Aldin Muhammad Fajar
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Abstract
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A new cinnamyl acid derivative, willughbein A (1) along with pinoresinol (2), alyterinate A (3), and scopoletin (4), were isolated from the roots of Willughbeia coriacea Wall. The structure of 1 has been determined based on HRESIMS, 1D, and 2D NMR spectral data. All of the isolates were evaluated for their cytotoxicity against three human cancer cells (HeLa, T47D, MCF-7, and P-388). Compound 3 showed moderate activity against P-388 cells with an IC50 value of 3.04 μg/mL.
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KEYWORD
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Willughbein A, Cinnamyl acid, Willughbeia coriacea, Cytotoxic
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