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KMID : 0620720200260020144
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Natural Product Sciences
2020 Volume.26 No. 2 p.144 ~ p.150
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Chemical Constituents of Nauclea vanderguchtii
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Nkouayeb Brice Maxime Nangmou
Azebaze Anatole Guy Blaise
Tabekoueng Georges Bellier
Tsopgni Willifred Dongmo Tekapi
Lenta Bruno Ndjakou
Frese Marcel
Sewald Norbert
Vardamides Juliette Catherine
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Abstract
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Phytochemical investigation of leaves, barks and roots of Nauclea vanderguchtii led to the isolation of sixteen compounds, which includes one citric acid derivative (2), one alkaloid (16), one peptide derivative (3), and twelve triterpenes (1, 4 - 13). These compounds were identified as rotundanonic acid (1), 2-hydroxy-1,2,3- propanetricarboxylic acid 2-methyl ester (2), asperphenamate (3), lupeol (4), stigmasterol (5), betulin (6), betulenic acid (7), stigmasterol 3-O-?-D-glucopyranoside (8), quinovic acid 3?-O-?-L-rhamnoside (9), ?-amyrin (10), 3-oxoquinovic acid (11), ursolic acid (12), hederagenin (13), rotundic acid (14), clethric acid (15), and naucleficine (16) by the analysis of their NMR spectroscopic data including 2D NMR spectra and by comparison of their spectroscopic data reported in the literature. Compounds 1 and 3 were isolated for the first time in the genus Nauclea, and compound 2 was isolated for the first time from the Rubiaceae family. Complete NMR assignations for 1 have been published for the first time.
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KEYWORD
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Nauclea vanderguchtii, Rubiaceae, triterpenes
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