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KMID : 0620720200260030183
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Natural Product Sciences
2020 Volume.26 No. 3 p.183 ~ p.190
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Global Regulators to Activate Silent Biosynthetic Gene Clusters
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Shim Sang-Hee
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Abstract
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Genome mining has recently emerged as a powerful strategy to discover novel microbial secondary metabolites. However, more than 50% of biosynthetic gene clusters are not transcribed under standardized laboratory culture condition. Several methods have been applied to activate silent biosynthetic gene clusters in the microbes so far. Among the regulatory systems for production of secondary metabolites, global regulators, which affect transcription of genes through regulatory cascades, typically govern the production of small molecules. In this review, global regulators to affect production of microbial secondary metabolites were discussed.
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KEYWORD
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Microbial natural products, Secondary metabolites, Biosynthetic gene clusters, Global regulators
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