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KMID : 0620720200260040279
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Natural Product Sciences
2020 Volume.26 No. 4 p.279 ~ p.320
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A New Cytotoxic Compound from Methanol Extract of Koordersiodendron pinnatum Merr. Leaves
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Fajriah Sofa
Megawati Megawati
Darmawan Akhmad
Lotulung Puspa Dewi N.
Salahuddin Salahuddin
Hanafi Muhammad
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Abstract
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Chemical investigation of the methanol extract of Koordersiodendron pinnatum Merr. leaves resulted a new naphthalene derivative, (Z)-4-(tetradec-3-enyl)naphthalene-1,2,7-triol (1), together with three known compounds, β-sitosterol (2), 20-epibryonolic acid (3), and scopoletin (4). The structure of the new compound was elucidated based on spectroscopic evidence. The isolated compounds (1-4) were tested their cytotoxic activities against the P-388 murine leukemia cell line and compound 1 has highest activity with IC50 1.94 μM.
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KEYWORD
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Naphthalene derivative, Koordersiodendron pinnatum Merr, cytotoxic activities, P-388 murine leukemia cell lines
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