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KMID : 0620720200260040283
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Natural Product Sciences
2020 Volume.26 No. 4 p.283 ~ p.288
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Stereoselective Microbial Hydroxylation of Progestin, Norethisterone by Using Aspergillus niger and Penicillium citrinum
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Azizuddin
Iqbal Muhammad
Musharraf Ghulam
Shahzad Saleem
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Abstract
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Microbial transformation of a potent progestin, norethisterone (17β-hydroxy-19-nor-17α-pregn-4-en-20-yn-3-one) (1) was carried out by using two filamentous fungi Aspergillus niger and Penicillium citrinum. Biotransformation of 1 with A. niger yielded a hydroxylated transformed product 10β,17β-diydroxy-19-nor-17α-pregn-4-en-20-yn-3-one (2) whereas 11β,17β-diydroxy-19-nor-17α-pregn-4-en-20-yn-3-one (3) was obtained through microbial transformation of 1 by P. citrinum. It is the first report of their production from 1 by using A. niger and P. citrinum with complete 1H- and 13C-NMR assignment. The structures of both metabolites were characterized by various spectroscopic techniques and reported data.
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KEYWORD
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Microbial transformation, Progestin, Norethisterone, Aspergillus niger, Penicillium citrinum
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