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KMID : 0620720200260040303
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Natural Product Sciences
2020 Volume.26 No. 4 p.303 ~ p.310
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Calyxaprenols A-D, New Merohexaprenoid Metabolites from the Marine Sponge Calyx sp.
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Kim Chang-Kwon
Gustafson Kirk R.
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Abstract
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Four new merohexapenoids named calyxaprenols A-D (1 - 4), together with the known compound haliclotriol A (5), have been isolated from the marine sponge Calyx sp. which was collected from the southwest islands of Palau. Based on comprehensive spectroscopic analyses, calyxaprenols A (1) and B (2) were determined to be pentacyclic hexaprenoids that are appended to a glycolic acid-substituted phenol moiety, whereas calyxaprenols C (3) and D (4) possess a tricyclic hexaprenoid skeleton joined to a hydroquinone ring. Identification of new merohexaprenoids from a Calyx sponge expands the known taxonomic distribution of this sparsely distributed class of marine metabolites and increases the chemical diversity described for this genus of marine sponge.
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KEYWORD
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Calyx sp, marine sponge, merohexaprenoid, calyxaprenol
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