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KMID : 0620720200260040317
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Natural Product Sciences
2020 Volume.26 No. 4 p.317 ~ p.325
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A New Stilbene Dimer and Other Chemical Constituents from Monanthotaxis littoralis with Their Antimicrobial Activities
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Dongmo Arnaud Joseph Nguetse
Ekom Steve Endeguele
Tamokou Jean-de-Dieu
Tagousop Cyrille Ngoufack
Harakat Dominique
Voutquenne-Nazabadioko Laurence
Ngnokam David
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Abstract
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A new dimer stilbene [Monalittorin (1)] and ten known compounds [engeletin (2), aurantiamide acetate (3), lupeol (4), friedelin (5), quercetin (6), tiliroside (7), rutoside (8), astragalin (9), isoquercitrin (10) and quercimeritroside (11)] have been isolated from the leaves of Monanthotaxis littoralis (Annonaceae). The structures of these compounds were established by interpretation of their data, mainly, HR-TOFESIMS, 1-D NMR (1H and 13C) and 2-D NMR (1H-1H COSY, HSQC, HMBC and NOESY) and by comparison with the literature. The evaluation of their antimicrobial activities against three bacteria (Staphylococcus aureus ATCC 25923, Escherichia coli S2 (1) and Pseudomonas aeruginosa PA01) and three fungal strains (Candida albicans ATCC10231, Candida tropicalis PK233 and Cryptococcus neoformans H99) using broth micro dilution method, showed the largest antimicrobial activities of EtOAc fraction and compounds 1, 5, 6, 8 and 11 (MIC = 8 - 64 μg/mL). In addition, EtOAc fraction presented synergistic effect with Vancomycin and fluconazole against the tested microorganisms.
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KEYWORD
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Monanthotaxis littoralis, Annonaceae, Monalittorin, Dimer stilbene, Antimicrobial activities, Synergistic effect
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