|
KMID : 0620720200260040340
|
|
Natural Product Sciences
2020 Volume.26 No. 4 p.340 ~ p.344
|
|
|
Molecular Networking-based De-replication Strategy Leads to the Isolation of a New Chromone from Pleosporales sp.
|
|
Kwon Ha-Eun
Kim Jun-Gu
Oh Jeong-Joo
Kim Jae-Jin
Kim Gyu-Hyeok
Hwang Bang-Yeon
Yim Joung-Han
Lee Dong-Ho
|
|
|
Abstract
|
|
|
|
A new chromone analogue (1) was isolated from an EtOAc-extract of Pleosporales sp. culture medium, together with five known chromones (2 - 6). The isolation workflow was guided by a Molecular Networking-based dereplication strategy. The chemical structure of the new compound was elucidated using NMR and MS spectroscopy, and the absolute configuration was established by the Mosher's method. All isolated compounds were evaluated for their inhibitory effects on lipopolysaccharide-induced nitirc oxide production in RAW 264.7 macrophages. Compound 1 showed marginal inhibitory activity with an IC50 value of 118.7 μM.
|
|
|
KEYWORD
|
|
|
Pleosporales sp., Chromone, Molecular Networking, Mosher's method, Nitric oxide production
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|