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KMID : 0620720210270030172
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Natural Product Sciences
2021 Volume.27 No. 3 p.172 ~ p.175
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Sesbagrandiflorain F, a New 2-Arylbenzofuran from the Stem Bark of Sesbania grandiflora L.
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Tanjung Mulyadi
Aldin Muhammad Fajar
Tjahjandarie Tjitjik Srie
Rahayu Devina Oktari
Gunawan Alfiah Nur Irza
Saputri Ratih Dewi
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Abstract
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Sesbagrandiflorain F (1), a novel 2-arylbenzofuran, and two more 2-arylbenzofurans (2-3), were isolated from the stem bark of Sesbania grandiflora L. Based on information HRESIMS data, 1D, and 2D NMR spectra, the structure of 1 was fully assigned. Compounds 1-3 were tested for cytotoxicity in MCF-7 and HeLa cells. Compounds 1 and 3 showed moderate activity against MCF-7 cells with an IC50 value of 2.68 and 4.08 μg/mL, respectively. Conversely, all of the isolates were inactive towards HeLa cells.
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KEYWORD
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Sesbagrandiflorain F, 2-Arylbenzofuran, Sesbania grandiflora, Cytotoxic
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