|
KMID : 0620720220280010006
|
|
Natural Product Sciences
2022 Volume.28 No. 1 p.6 ~ p.12
|
|
|
Sesquiterpenoids from the Stem Bark of Aglaia grandis
|
|
Harneti Desi
Permatasari Atika Ayu
Anisshabira Amallya
Al Arofatus Naini
Nurlelasari
Mayanti Tri
Maharani Rani
Safari Agus
Hidayat Ace Tatang
Farabi Kindi
Supratman Unang
Azmi Mohamad Nurul
Shiono Yoshihito
|
|
|
Abstract
|
|
|
|
Five sesquiterpenoids, 7-epi-eudesm-4(15)-ene,1β,6α-diol (1), 7-epi-eudesm-4(15)-ene,1β,6α-diol (2), saniculamoid D (3), aphanamol I (4), and 4β,10α-dihydroxyaromadendrane (5), were isolated from the stem bark of Aglaia grandis. The compounds’ (1-5) chemical structures were identified by spectroscopic data including, IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, 1H-1H COSY), and HRTOFMS, as well as by comparing with the previously reported spectral data. Therefore, this study described the structural elucidation of compounds 1-5 and evaluated their cytotoxic effects against Hela cervical and B16F10 melanoma cells for the first time, but no significant result was discovered.
|
|
|
KEYWORD
|
|
|
Aglaia grandis, HeLa cell lines, B16F10 cell lines, Meliaceae, sesquiterpenoids
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|