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KMID : 0620720220280010033
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Natural Product Sciences
2022 Volume.28 No. 1 p.33 ~ p.39
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Lignans and Macrolides from the Leaves of Houttuynia cordata with Inhibitory Activity against NO Production in Murine Macrophage RAW 264.7 Cells
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Ahn Jong-Min
Chae Hee-Sung
Chin Young-Won
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Abstract
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Eight lignans (1-8) and two macrolides (9-10) were isolated from the CHCl3-soluble fraction of Houttuynia cordata Thumb (Saururaceae). Structures of isolates were elucidated by extensive spectroscopic methods. Fatty acid-derived macrolides (9-10) have rarely been reported from nature. All the isolates were tested for their inhibitory activities against NO production in RAW 264.7 cells stimulated by LPS. It was found that compounds 3 and 9 remarkably down-regulated LPS-induced NO production with IC50 values, 5.4 and 40.3 μM, respectively, without cytotoxicity.
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KEYWORD
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Anti-inflammatory, Houttuynia cordata, Lignans, Macrolides
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