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KMID : 0620720220280020053
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Natural Product Sciences
2022 Volume.28 No. 2 p.53 ~ p.62
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A New Dimeric Lignan from the Stems of Willughbeia edulis
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Nguyen Hai Xuan
Do Truong Nhat Van
Le Tho Huu
Dang Phu Hoang
Nguyen Mai Thanh Thi
Nguyen Nhan Trung
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Abstract
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As part of our continued study on the chemical constituents of Willughbeia edulis stems, a new dimeric lignan named edulignan (1) was isolated from its EtOAc-soluble extract. Based on NMR spectroscopic interpretation, the planar structure of 1 has been suggested to have two 2-substituted 4-chromanone subunits with different stereochemical configurations. In addition, the MS/MS analysis of the products obtained by acidcatalyzed hydrolysis of 1 was supportive of its structure. Unfornatually, the new compound 1 did not show α- glucosidase inhibitory activity with an IC50 value > 250 μM.
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KEYWORD
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Willughbeia edulis, Apocynaceae, Dimeric lignan, α-Glucosidase
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