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KMID : 0620720220280020058
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Natural Product Sciences
2022 Volume.28 No. 2 p.58 ~ p.71
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Two New Flavanones from the Leaves of Flemingia lineata (L.) Aiton
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Tanjung Mulyadi
Tjahjandarie Tjitjik Srie
Mardhiyyah Shola
Rahman Ghinsha Zakatina
Aldin Muhammad Fajar
Saputri Ratih Dewi
Ahmat Norizan
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Abstract
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Three isoprenylated flavanones were isolated from the leaves of Flemingia lineata (L.) Aiton. Among them are two new flavanones, flemilineatins A and B (1 - 2), along with 6-isoprenyl eridioctyol (3). Their structures were determined using HRESIMS data and NMR spectra. Flavanones 1 - 3 were assayed in the HeLa cancer cells. Compound 1 showed moderate activity with an IC50 value of 11.2 μM.
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KEYWORD
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Flemingia lineata, flemilineatins A-B, flavanone, cytotoxicity
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