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KMID : 0620720220280020062
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Natural Product Sciences
2022 Volume.28 No. 2 p.62 ~ p.88
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Chemical Profile and Cytotoxicity Activity of Stem-bark of Anacardium occidentale
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Shehu Abdullahi
Ponnapalli Mangala Gowri
Mahboob Mohd
Prabhakar Pitta Venkata
Olatunji Gabriel Ademola
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Abstract
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Column chromatographic fractionation of the methanol and ethyl acetate extracts of the stem-bark of Anacardium occidentale led to the isolation of five compounds (1-5). Their structures were determined by spectroscopic means by comparing spectral data to be β-sitosterol (1), 2,4-dihydroxy acetophenone (2), 1- monolinolein (3), ethyl oleate (4) and β-sitosterol-3-O-β-D-glucopyranoside (5). These compounds were evaluated for cytotoxicity against human cancer cell lines: A549, SCOV3 and rat normal cell line NRK49f. Compounds 2-5 were for the first time isolated from A. occidentale.
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KEYWORD
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Anacardium occidentale, Anacardiaceae, β-sitosterol, MTT assay, cytotoxicity
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