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KMID : 0620720220280030093
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Natural Product Sciences
2022 Volume.28 No. 3 p.93 ~ p.104
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Bioprospecting of Endophytic Fungi as Promising Anti-MRSA Agents
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Wei Yee-Min
Tan Joo-Shun
Tang Hock-Wei
Tong Woei-Yenn
Leong Chean-Ring
Tan Wen-Nee
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Abstract
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Methicillin-resistant Staphylococcus aureus (MRSA) is a serious threat to the global healthcare system. Ineffective and resistance to antibiotic treatments have increased morbidity and mortality rates worldwide. New and effective antibiotics are needed to combat against bacterial resistance. Endophytic fungi are crucial reservoirs of novel bioactive metabolites. In particular, the secondary metabolites show promising therapeutic potential, notably, antibacterial. This review discussed the emerging potential of endophytic fungi as anti-MRSA agents. The ecological sources of endophytic fungi were discussed with the synthesis of bioactive metabolites. The mode of antibacterial actions was elucidated to give a better understanding of the mechanisms involved. This review may serve as an important reference for future discovery and developments of anti-MRSA agents from endophytic fungi.
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KEYWORD
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Antibiotic, bioactive metabolites, endophytic fungi, methicillin-resistant, MRSA, Staphylococcus aureus
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