|
KMID : 0620720220280030115
|
|
Natural Product Sciences
2022 Volume.28 No. 3 p.115 ~ p.120
|
|
|
Cytotoxic Neoflavonoids and Chalcones from the Heartwood of Dalbergia melanoxylon
|
|
Chung Ha-Sook
|
|
|
Abstract
|
|
|
|
Ten compounds, consisting of neoflavonoids (1-5), isoflavonoids (6 and 7), flavanone (8), and chalcones (9 and 10) were isolated from the ethyl acetate and n-butanol-soluble fractions of the heartwood of Dalbergia melanoxylon. The chemical structures were identified on the basis of spectroscopic evidence and compared to previously reported spectra. Compounds 1-10 were evaluated for cytotoxicity against HCT116 human colorectal cancer, MDA-MB-231 human metastatic breast cancer, and A2058 human melanoma cell lines. Among them, compounds 3 and 10 showed the strongest cytotoxic activity with IC50 values of 11.92 ± 1.07 μM, 10.83 ± 1.02 μM, and 14.37 ± 1.02 μM, 13.62 ± 1.09 μM against HCT116 and MDA-MB-231 cell lines, respectively. Compounds 9 and 10 also had cytotoxic activity with IC50 values of 13.49 ± 1.18 μM and 9.82 ± 0.91 μM against A2058 cell lines, respectively. To the best our knowledge, compounds 2 and 5-10 were isolated from this source for the first time.
|
|
|
KEYWORD
|
|
|
Dalbergia melanoxylon, heartwood, HCT116, MDA-MB-231, A2058, neoflavonoid, chalcone
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|