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KMID : 0620720230290010038
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Natural Product Sciences
2023 Volume.29 No. 1 p.38 ~ p.41
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Xanthones and 4-Phenylcoumarins from the Twigs of Mesua beccariana (Baill.) Kosterm
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Mulyadi Tanjung
Tjitjik Srie Tjahjandarie
Muhammad Fajar Aldin
Shola Mardhiyyah
Ishomatul Maqfiroh
Ratih Dewi Saputri
Norizan Ahmat
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Abstract
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Two xanthones and 4-phenylcoumarins were isolated from the twigs of Mesua beccariana (Baill.) Kosterm. Among them, one new xanthone, beccarianin A (1), along with 7-isoprenyl-jacareubin (2), mammea A/AA cyclo F (3), and mammea A/BA cyclo F (4). These structures were determined by spectrometric and spectroscopic methods, HRESIMS data, NMR, and UV spectra. Two xanthones (1-2) and two 4-phenyl- coumarins (3-4) were evaluated for their cytotoxic effect on the HeLa cells. Compound 1 showed active activity (IC50 = 8.2 μM), and compounds 3-4 showed moderate activity (IC50 = 12.3 and 15.6 μM, respectively).
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KEYWORD
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Mesua beccariana, beccarianin A, xanthone, 4-phenylcoumarin, cytotoxic
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