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KMID : 0620720230290040263
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Natural Product Sciences
2023 Volume.29 No. 4 p.263 ~ p.267
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Chemical Constituents from the Leaves of Dischidia nummularia (Asclepiadaceae)
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Sonni Maurit Benu
Riga Riga
Lia Dewi Juliawaty
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Abstract
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The investigation of chemical constituents from Dischidia nummularia leaves, which belongs to the Asclepiadaceae family, resulted in five known compounds. Three compounds were suggested as triterpenoid derivatives, namely glutinol (1), α-amyrin (2) and friedelin (3). In addition, two other compounds were a steroid derivative (4), i.e., stigmast-5-ene-3β-ol (4) and a xanthone derivative, i.e., α-mangostin (5). The chemical structures of 1?5 were elucidated based on detailed analysis of NMR (1D and 2D) spectroscopic data and compared with literature data. Interestingly, compounds 1 and 5 were first obtained from the Asclepiadaceae family, while compound 2 was isolated for the first time from the Dischidia genus. The acetone crude extract and compounds 1?3 showed weak cytotoxicity against murine leukemia P-388 cells. After all, the current study is the first report of a phytochemical study of D. nummularia.
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KEYWORD
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Dischidia nummularia, Triterpenoid, Steroid, Xanthone, Cytotoxicity
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