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KMID : 0620720230290040281
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Natural Product Sciences
2023 Volume.29 No. 4 p.281 ~ p.286
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Optimization of the Extraction Process for Bioactive Compounds from the Root Barks of Moringa oleifera
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Do Hoang Giang
Tran Van Hien
Nguyen Thi Thu Minh
Nguyen Thu Uyen
Hoang Thuy Duong
Bui Thi Nhat Le
Mai Thi Thu Ha
Nguyen Tien Dat
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Abstract
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The optimal condition for Moringa oleifera root barks extraction was determined using response surface methodology and Box-Behnken Design. The actual optimal condition of the factors was 65oC, ethanol 60%, 40 (mL/g) liquid-to-solid ratio with 240 minutes extraction time. The enrichment of phenolic compounds sharply affected the antioxidant, and inhibitions of α-amylase enzyme, as well as, the anti-inflammatory effect of the extract from M. oleifera root barks. The extract in the optimal condition exhibited better 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging and α-amylase inhibitory activities than those of positive controls. Also, the extract showed weak hydroxyl free radical scavenging and nitric oxide (NO) production inhibitory effects. These revealed a simple and promising method for the preparation of bioactive products from the root bark of M. oleifera.
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KEYWORD
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Moringa oleifera, Phenolic, Antioxidant, Anti-inflammation, α-Amylase
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