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KMID : 0620720230290040287
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Natural Product Sciences
2023 Volume.29 No. 4 p.287 ~ p.290
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Macagigantin A, A New Flavonoid from Macaranga gigantea (Rchb.f & Zoll.) Mull.Arg
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Mulyadi Tanjung
Tjitjik Srie Tjahjandarie
Muhammad Fajar Aldin
Shola Mardhiyyah
Norizan Ahmat
Ratih Dewi Saputri
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Abstract
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A new flavonol, macagigantin A (1), and three known flavonols (2?4) were isolated from Macaranga gigantea leaves. The structure of macagigantin A was fully assigned by 1D and 2D NMR, UV, and high-resolution mass spectra data. The cytotoxic activity of 1?4 was evaluated against 4T1, P-388, and HeLa cells. Compound 1 showed potent activity against 4T1 cells with an IC50 value of 1.18 μg/mL, and compound 3 showed moderate activity against P-388 cells (IC50 value of 2.54 μg/mL).
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KEYWORD
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Macagigantin A, Flavonoid, Macaranga gigantea, Cytotoxic
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