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KMID : 0620720230290040349
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Natural Product Sciences
2023 Volume.29 No. 4 p.349 ~ p.356
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Inhibition of α-Glucosidase by Abietane-Type Diterpenoids Isolated from Roots of Salvia miltiorrhiza
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Nguyen Viet Phong
Le Thi Thanh
Kwon Mi-Jeong
Lee You-Mie
Min Byung-Sun
Kim Jeong-Ah
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Abstract
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Salvia miltiorrhiza is a traditional medicinal plant used in Asian medicine for various therapeutic purposes. This plant contains numerous bioactive secondary metabolites, particularly abietane-type diterpenoids. In this study, 16 abietane-type diterpenoids were isolated from S. miltiorrhiza root extracts and structurally identified through advanced spectroscopic techniques. Among them, tanshinone IIA (6) and 15,16-dihydro- tanshinone I (11) exhibited potent α-glucosidase inhibition, with IC50 values of 48.38 ± 0.57 and 48.02 ± 0.47 μM, respectively. Enzyme kinetic studies revealed that these compounds served as non-competitive inhibitors of α-glucosidase. Our findings indicate that natural compounds from S. miltiorrhiza show promise as safe and effective α-glucosidase inhibitors, providing an alternative approach to diabetes treatment. This study contributes to the growing interest in utilizing natural sources for α-glucosidase inhibition and their potential application in healthcare and disease management.
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KEYWORD
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Salvia miltiorrhiza, diterpenoid, α-glucosidase inhibition, enzyme kinetics
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