KMID : 0620920090410100707
|
|
Experimental & Molecular Medicine 2009 Volume.41 No. 10 p.707 ~ p.716
|
|
Sequential evolution of IL-17 responses in the early period of allograft rejection
|
|
Min Sang-Il
Ha Jong-Won Park Chung-Gyu Won Jae-Kyung Park Yang-Jin Min Seung-Kee Kim Sang-Joon
|
|
Abstract
|
|
|
In addition to CD4+CD25+Foxp3+ regulatory T (Treg) cells which protect against autoimmune tissue injury, IL-17-producing CD4+ T (Th17) cells have been recently described and shown to play a crucial role in autoimmune injury. It appears that there is a reciprocal developmental pathway between Th17 and Treg cells. Although IL-17 is known to be associated with allograft rejection, the cellular source of IL-17 and the nature of Th17 in the context of allograft rejection remain unknown. In the current study, the dynamics of Treg and IL-17-producing cells after syngeneic and allogeneic transplantation were examined using a wild-type murine cardiac transplantation model. Ly6G+ cells were found to produce IL-17 during the early postoperative period and CD8+ as well as CD4+ T cells were also found to produce IL-17 during alloimmune response. Graft-infiltrating Ly6G+, CD4+, and even CD8+ cells were found to express IL-17 highly compared to those in spleen. Although the frequencies of Th17 and Treg were found to gradually increase in both syngeneic and allogeneic recipients, Th17/Treg ratios were significantly higher in recipients with allograft rejection than in syngeneic recipients. In conclusion, IL-17 is produced by neutrophils during the early postoperative period and subsequently by Th17 and CD8+ T cells during allograft rejection. Th17/Treg imbalance is associated with the development of allograft rejection. This study would provide basic information on Th17 biology for future investigation in the field of transplantation.
|
|
KEYWORD
|
|
graft rejection, interleukin-17, neutrophils, T-lymphocytes, regulatory
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|