KMID : 0624620160490090508
|
|
BMB Reports 2016 Volume.49 No. 9 p.508 ~ p.513
|
|
Suppression of Akt-HIF-1¥á signaling axis by diacetyl atractylodiol inhibits hypoxia-induced angiogenesis
|
|
Choi Sik-Won
Lee Kwang-Sik Lee Jin-Hwan Kang Hyeon-Jung Lee Mi-Ja Kim Hyun-Young Park Kie-In Kim Sun-Lim Shin Hye-Kyoung Seo Woo-Duck
|
|
Abstract
|
|
|
Hypoxia-inducible factor (HIF)-1¥á is a key regulator associated with tumorigenesis, angiogenesis, and metastasis. HIF-1¥á regulation under hypoxia has been highlighted as a promising therapeutic target in angiogenesis-related diseases. Here, we demonstrate that diacetyl atractylodiol (DAA) from Atractylodes japonica (A. japonica) is a potent HIF-1¥á inhibitor that inhibits the Akt signaling pathway. DAA dose-dependently inhibited hypoxia-induced HIF-1¥á and downregulated Akt signaling without affecting the stability of HIF-1¥á protein. Furthermore, DAA prevented hypoxia-mediated angiogenesis based on in vitro tube formation and in vivo chorioallantoic membrane (CAM) assays. Therefore, DAA might be useful for treatment of hypoxia-related tumorigenesis, including angiogenesis.
|
|
KEYWORD
|
|
Akt-HIF-1¥á signaling, Angiogenesis, Diacetyl atractylodiol, HIF-1¥á, Hypoxia
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|