KMID : 0811720220260010059
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Korean Journal of Physiology & Pharmacology 2022 Volume.26 No. 1 p.59 ~ p.65
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Decrease of glycogen synthase kinase 3¥â phosphorylation in the rat nucleus accumbens shell is necessary for amphetamine-induced conditioned locomotor activity
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Shin Joong-Keun
Kim Wha-Young Rim Ha-Eun Kim Jeong-Hoon
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Abstract
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Phosphorylation levels of glycogen synthase kinase 3¥â (GSK3¥â) negatively correlated with psychomotor stimulant-induced locomotor activity. Locomotor sensitization induced by psychomotor stimulants was previously shown to selectively accompany the decrease of GSK3¥â phosphorylation in the nucleus accumbens (NAcc) core, suggesting that intact GSK3¥â activity in this region is necessary for psychomotor stimulants to produce locomotor sensitization. Similarly, GSK3¥â in the NAcc was also implicated in mediating the conditioned effects formed by the associations of psychomotor stimulants. However, it remains undetermined whether GSK3¥â plays a differential role in the two sub-regions (core and shell) of the NAcc in the expression of drug-conditioned behaviors. In the present study, we found that GSK3¥â phosphorylation was significantly lower in the NAcc shell obtained from rats expressing amphetamine (AMPH)-induced conditioned locomotor activity. Further, we demonstrated that these effects were normalized by treatment with lithium chloride, a GSK3¥â inhibitor. These results suggest that the behavior produced by AMPH itself and a conditioned behavior formed by associations with AMPH are differentially mediated by the two sub-regions of the NAcc.
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KEYWORD
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Amphetamine, Classical conditioning, GSK3beta, Lithium chloride, Nucleus accumbens
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