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KMID : 0880420010020040192
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Korean Journal of Radiology
2001 Volume.2 No. 4 p.192 ~ p.196
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Diffusion-Weighted MR Imaging in Biopsy-Proven Creutzfeldt-Jakob Disease
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Kee Hyun Chang/Hyo Cheol Kim
Kee Hyun Chang/In Chan Song/Sang Hyun Lee/Bae Ju Kwon/Moon Hee Han/Sang Yun Kim*
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Abstract
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Objective: To compare conventional and diffusion-weighted MR imaging in terms of their depiction of the abnormalities occurring in Creutzfeldt-Jakob disease.
Materials and Methods: We retrospectively analyzed the findings of conventional (T2-weighted and fluid-attenuated inversion recovery) and diffusion-weighted MR imaging in four patients with biopsy-proven Creutzfeldt-Jakob disease. The signal intensity of the lesion was classified by visual assessment as markedly high, slightly high, or isointense, relative to normal brain parenchyma.
Results: Both conventional and diffusion-weighted MR images demonstrated bilateral high signal intensity in the basal ganglia in all four patients. Cortical lesions were observed on diffusion-weighted MR images in all four, and on fluid-attenuated inversion recovery MR images in one, but in no patient on T2-weighted images. Conventional MR images showed slightly high signal intensity in all lesions, while diffusion-weighted images showed markedly high signal intensity in most.
Conclusion: Diffusion-weighted MR imaging is more sensitive than its conventional counterpart in the depiction of Creutzfeldt-Jakob disease, and permits better detection of the lesion in both the cerebral cortices and basal ganglia.
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KEYWORD
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Brain, infection, Creutzfeldt-Jakob disease, Dementia, Magnetic resonance (MR), diffusion study,
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