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KMID : 0880420010020040210
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Korean Journal of Radiology
2001 Volume.2 No. 4 p.210 ~ p.215
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Detection of Malignant Primary Hepatic Neoplasms with Gadobenate Dimeglumine (Gd-BOPTA) Enhanced T1-Weighted Hepatocyte Phase MR Imaging: Results of Off-site Blinded Review in a Phase-II Multicenter Trial
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Sanjay Saini/Constantino S Pena
Sanjay Saini/Richard L Baron/Bernd A Hamm/Giovanni Morana/Roberto Caudana/Andrea Giovagnoni/Andrea Villa/Alessandro Carriero/Didier Mathieu/Michael W Bourne/Miles A Kirchin/Gianpaolo Pirovano/Alberto Spinazzi
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Abstract
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Objective: To investigate the efficacy of gadobenate dimeglumine (Gd-BOPTA) enhanced MR imaging for the detection of liver lesions in patients with primary malignant hepatic neoplasms.
Materials and methods: Thirty-one patients with histologically proven primary malignancy of the liver were evaluated before and after administration of Gd-BOPTA at dose 0.05 or 0.10 mmol/kg. T1-weighted spin echo (T1W-SE) and gradient echo (T1W-GRE) images were evaluated for lesion number, location, size and confidence by three off-site independent reviewers and the findings were compared to reference standard imaging (intraoperative ultrasound, computed tomography during arterial portography or lipiodol computed tomography). Results were analyzed for significance using a two-sided McNemar's test.
Results: More lesions were identified on Gd-BOPTA enhanced images than on unenhanced images and there was no significant difference in lesion detection between either concentration. The largest benefit was in detection of lesions under 1 cm in size (7 to 21, 9 to 15, 16 to 18 for reviewers A, B, C respectively). In 68% of the patients with more than one lesion, Gd-BOPTA increased the number of lesions detected.
Conclusion: Liver MR imaging after Gd-BOPTA increases the detection of liver lesions in patients with primary malignant hepatic neoplasm.
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KEYWORD
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Liver neoplasms, MR, Liver neoplasms, diagnosis, Magnetic resonance (MR), contrast media,
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