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KMID : 0880420080090010010
Korean Journal of Radiology
2008 Volume.9 No. 1 p.10 ~ p.18
Correlation between High Resolution Dynamic MR Features and Prognostic Factors in Breast Cancer
Lee Shin-Ho

Cho Nariya
Kim Seung-Ja
Cha Joo-Hee
Cho Kyung-Soo
Ko En-Sook
Moon Woo-Kyung
Abstract
Objective : To correlate high resolution dynamic MR features with prognostic factors in breast cancer.

Materials and Methods : One hundred and ninety-four women with invasive ductal carcinomas underwent dynamic MR imaging using T1-weighted three-dimensional fast low-angle shot (3D-FLASH) sequence within two weeks prior to surgery. Morphological and kinetic MR features were determined based on the breast imaging and reporting data system (BI-RADS) MR imaging lexicon. Histological specimens were analyzed for tumor size, axillary lymph node status, histological grade, expression of estrogen receptor (ER), expression of progesterone receptor (PR), and expression of p53, c-erbB-2, and Ki-67. Correlations between the MR features and prognostic factors were determined using the Pearson x2 test, linear-by-linear association, and logistic regression analysis.

Results : By multivariate analysis, a spiculated margin was a significant, independent predictor of a lower histological grade (p < 0.001), and lower expression of Ki-67 (p = 0.007). Rim enhancement was significant, independent predictor of a higher histological grade (p < 0.001), negative expression of ER (p = 0.001), negative expression of PR (p < 0.001) and a larger tumor size (p = 0.006). A washout curve may predict a higher level of Ki-67 (p = 0.05). Most of the parameters of the initial enhancement phase cannot predict the status of the prognostic factors. Only the enhancement ratio may predict a larger tumor size (p = 0.05).

Conclusion : Of the BI-RADS-MR features, a spiculated margin may predict favorable prognosis, whereas rim enhancement or washout may predict unfavorable prognosis of breast cancer.
KEYWORD
Breast neoplasms, Breast, MR, Prognostic factors
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