|
KMID : 0880420090100050447
|
|
Korean Journal of Radiology
2009 Volume.10 No. 5 p.447 ~ p.454
|
|
|
MR Diagnosis of a Pulmonary Embolism: Comparison of P792 and Gd-DOTA for First-Pass Perfusion MRI and Contrast-Enhanced 3D MRA in a Rabbit Model
|
|
Shella D. Keilholz
Ugur Bozlar
Naomi Fujiwara
Jaime F. Mata
Stuart S. Berr
Klaus D. Hagspiel
Claire Corot
|
|
|
Abstract
|
|
|
Objective: To compare P792 (gadomelitol, a rapid clearance blood pool MR contrast agent) with gadolinium-tetraazacyclododecanetetraacetic acid (Gd-DOTA), a standard extracellular agent, for their suitability to diagnose a pulmonary embolism (PE) during a first-pass perfusion MRI and 3D contrast-enhanced (CE) MR angiography (MRA).
Materials and Methods : A perfusion MRI or CE-MRA was performed in a rabbit PE model following the intravenous injection of a single dose of contrast agent. The time course of the pulmonary vascular and parenchymal enhancement was assessed by measuring the signal in the aorta, pulmonary artery, and lung parenchyma as a function of time to determine whether there is a significant difference between the techniques. CE-MRA studies were evaluated by their ability to depict the pulmonary vasculature and following defects between 3 seconds and 15 minutes after a triple dose intravenous injection of the contrast agents.
Results: The P792 and Gd-DOTA were equivalent in their ability to demonstrate PE as perfusion defects on first pass imaging. The signal from P792 was significantly higher in vasculature than that from Gd-DOTA between the first and the tenth minutes after injection. The results suggest that a CE-MRA PE could be reliably diagnosed up to 15 minutes after injection.
Conclusion: P792 is superior to Gd-DOTA for the MR diagnosis of PE.
|
|
|
KEYWORD
|
|
|
Pulmonary embolism, P792, Angiography, perfusion
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
    
|