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KMID : 0880420100110030269
Korean Journal of Radiology
2010 Volume.11 No. 3 p.269 ~ p.277
MRI Findings of Primary CNS Lymphoma in 26 Immunocompetent Patients
Zhang Dong

Hu Liang-Bo
Henning Tobias D
Ravarani Elisabeth M
Zou Li-Guang
Feng Xiao-Yuan
Wang Wen-Xian
Wen Li
Abstract
Objective: To record the MR imaging features of primary central nervous system lymphoma (PCNSL) and compare these features in monofocal and multifocal disease.

Materials and Methods: Twenty-one cases of monofocal disease were compared to five cases of multifocal disease. All patients were examined by non-enhanced and contrast-enhanced MRI. Tumor location, tumor size, signal intensity, enhancement characteristics, age distribution, peritumoral edema, cystic changes, and the presence of calcifications were assessed. The MRI features were compared between the monofocal and multifocal disease cases.

Results: The 26 cases, including both the monofocal and multifocal cases, exhibited 37 lesions. Contrast-enhanced images showed variable enhancement patterns: homogeneous enhancement (33 lesions), ring-like enhancement (2), and ¡¯open-ring-like¡¯ enhancement (2). The ¡¯notch sign¡¯ was noted in four of 33 homogeneously enhancing lesions. One case of hemorrhage and three cases of cystic formation were observed. Intra-tumoral calcification was not found. The frontal lobe, the corpus callosum and the basal ganglia were commonly affected in both the monofocal and multifocal groups. Tumor size differed significantly between the two groups (t = 3.129, p < 0.01) and mildly or moderately enhanced lesions were more frequently found in the monofocal group (p < 0.05). There was no statistical difference between perifocal edema (p > 0.05) and the signal characteristics (p > 0.05) between the two groups.

Conclusion: Our data show that PCNSL has a variable enhancement pattern on MR images. We first reported two lesions with an ¡¯open-ring¡¯ enhancement as well as four cases with a ¡¯notch sign¡¯. Monofocal PCNSL cases typically have larger sized tumors with mild or moderate enhancement.
KEYWORD
Brain neoplasm, Lymphoma, Magnetic resonance (MR), Computed tomography (CT)
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