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KMID : 0880420100110030327
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Korean Journal of Radiology
2010 Volume.11 No. 3 p.327 ~ p.332
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Cellular Density Evaluation for Malignant Lymphoma Using Equivalent Cross-Relaxation Rate Imaging - Initial Experience
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Nishiofuku Hideyuki
Matsushima Shigeru
Inaba Yoshitaka
Yamaura Hidekazu
Sato Yozo
Morishima Yasuo
Kichikawa Kimihiko
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Abstract
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Objective: Equivalent cross-relaxation rate (ECR) imaging is an MRI technique used to evaluate quantitatively a change in the protein-water interaction. We aimed to evaluate retrospectively the usefulness of ECR imaging for the histologic classification of malignant lymphoma (ML).
Materials and Methods: Institutional Review Board approval was obtained and all patients provided informed consent. The study subjects included 15 patients with untreated ML who were histologically diagnosed with follicular lymphoma (FL; n = 8) or diffuse large B-cell lymphoma (DLBCL; n = 7). All patients underwent ECR imaging and the offset frequency was set at 7 ppm.
Results: The median ECR values were 71% (range; 60.7 to 75.5) in FL and 54% (50.8 to 59.4) in DLBCL (p = 0.001). The median cellular density was 1.5 ± 0.17 × 106 / mm2 in FL and 1.0 ± 0.70 × 106 / mm2 in DLBCL (p = 0.001). The correlation coefficient between the ECR values and cellular density in ML was 0.88 (p = 0.001). In FL and DLBCL, assuming ECR value cut-off points of 60%, both sensitivity and specificity were 100%.
Conclusion: A strong correlation between ECR and cellular density in ML is demonstrated and the ECR may be a useful technique to differentiate between FL and DLBCL.
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KEYWORD
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Equivalent cross-relaxation rate imaging, Cellular imaging, Malignant lymphoma, Molecular imaging
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