KMID : 0880420110120010015
|
|
Korean Journal of Radiology 2011 Volume.12 No. 1 p.15 ~ p.24
|
|
Diffusion and Perfusion Characteristics of MELAS (Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episode) in Thirteen Patients
|
|
Kim Ji-Hye
Lim Myung-Kwan Jeon Tae-Yeon Rha Jung-Ho Eo Hong Yoo So-Young Shu Chang-Hae
|
|
Abstract
|
|
|
Objective: We analyzed the diffusion and perfusion characteristics of acute MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episode) lesions in a large series to investigate the controversial changes of the apparent diffusion coefficient (ADC) that were reported in prior studies.
Materials and Methods: We analyzed 44 newly appearing lesions during 28 stroke-like episodes in 13 patients with MELAS. We performed a visual assessment of the MR images including the ADC and perfusion maps, comparison of the ADC between the normal and abnormal areas, comparison of % ADC between the 44 MELAS lesions and the 30 acute ischemic infarcts. In addition, the patterns of evolution on follow-up MR images were analyzed.
Results: Decreased, increased, and normal ADCs were noted in 16 (36%), 16 (36%), and 12 (27%) lesions, respectively. The mean % ADC was 102 ¡¾ 40.9% in the MELAS and 64 ¡¾ 17.8% in the acute vascular infarcts (p < 0.001), while perfusion imaging demonstrated hyper-perfusion in six acute MELAS lesions. On follow-up images, resolution, progression, and tissue loss were noted in 10, 4, and 17 lesions, respectively.
Conclusion: The cytotoxic edema gradually evolves following an acute stroke-like episode in patients with MELAS, and this may overlap with hyper-perfusion and vasogenic edema. The edematous swelling may be reversible or it may evolve to encephalomalacia, suggesting irreversible damage.
|
|
KEYWORD
|
|
Mitochondrial encephalopathy, Diffusion weighted imaging, Perfusion MR imaging, Stroke
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|