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KMID : 0880420140150040456
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Korean Journal of Radiology
2014 Volume.15 No. 4 p.456 ~ p.463
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Contrast-Induced Nephropathy in Patients Undergoing Intravenous Contrast-Enhanced Computed Tomography in Korea: A Multi-Institutional Study in 101487 Patients
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Lee Joong-Yub
Cho Jeong-Yeon
Lee Hak-Jong
Jeong Yong-Yeon
Kim Chan-Kyo
Park Byung-Kwan
Sung Deuk-Jae
Kang Byung-Chul
Jung Sung-Il
Lee Eun-Ju
Yi Boem-Ha
Park Seong-Jin
Kim Jong-Chul
Jung Dae-Chul
Sung Chang-Kyu
Kim Yong-Soo
Lee Young-Rae
Kim Sun-Ho
Yoon Seong-Kuk
Park Byung-Joo
Kim Seung-Hyup
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Abstract
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Objective: To evaluate the prevalence of known risk factors for contrast-induced nephropathy (CIN) and their association with the actual occurrence of CIN in patients undergoing intravenous contrast-enhanced computed tomography (CECT) in Korea.
Materials and Methods: Patients who underwent CECT in 2008 were identified in the electronic medical records of 16 tertiary hospitals of Korea. Data on demographics, comorbidities, prescriptions and laboratory test results of patients were collected following a standard data extraction protocol. The baseline renal function was assessed using the estimated glomerular filtration rate (eGFR). We identified the prevalence of risk factors along the eGFR strata and evaluated their influence on the incidence of CIN, defined as a 0.5 mg/dL or 25% increase in serum creatinine after CECT.
Results: Of 432425 CECT examinations in 272136 patients, 140838 examinations in 101487 patients met the eligibility criteria for analysis. The mean age of the participants was 57.9 ± 15.5 years; 25.1% of the patients were older than 70 years. The prevalence of diabetes mellitus was 11.9%, of hypertension 13.7%, of gout 0.55% and of heart failure was 1.7%. Preventive measures were used in 40238 CECT examinations (28.6%). The prevalence of risk factors and use of preventive measures increased as the renal function became worse. A CIN was occurred after 3103 (2.2%) CECT examinations, revealing a significant association with decreased eGFR, diabetes mellitus, and congestive heart failure after adjustment.
Conclusion: Risk factors for CIN are prevalent among the patients undergoing CECT. Preventive measures were seemingly underutilized and a system is needed to improve preventive care.
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KEYWORD
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Contrast-induced nephropathy, Contrast-enhanced computed tomography, Prevalence, Risk factor
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