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KMID : 0880420160170020281
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Korean Journal of Radiology
2016 Volume.17 No. 2 p.281 ~ p.288
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F-18 Sodium Fluoride Positron Emission Tomography/Computed Tomography for Detection of Thyroid Cancer Bone Metastasis Compared with Bone Scintigraphy
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Lee Hyun-Jong
Lee Won-Woo
Park So-Yeon
Kim Sang-Eun
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Abstract
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Objective: The aim of the study was to compare the diagnostic performances of F-18 sodium fluoride positron emission tomography/computed tomography (bone PET/CT) and bone scintigraphy (BS) for the detection of thyroid cancer bone metastasis.
Materials and Methods: We retrospectively enrolled 6 thyroid cancer patients (age = 44.7 ± 9.8 years, M:F = 1:5, papillary:follicular = 2:4) with suspected bone metastatic lesions in the whole body iodine scintigraphy or BS, who subsequently underwent bone PET/CT. Pathologic diagnosis was conducted for 4 lesions of 4 patients.
Results: Of the 17 suspected bone lesions, 10 were metastatic and 7 benign. Compared to BS, bone PET/CT exhibited superior sensitivity (10/10 = 100% vs. 2/10 = 20%, p = 0.008), and accuracy (14/17 = 82.4% vs. 7/17 = 41.2%, p < 0.025). The specificity (4/7 = 57.1%) of bone PET/CT was not significantly different from that of BS (5/7 = 71.4%, p > 0.05).
Conclusion: Bone PET/CT may be more sensitive and accurate than BS for the detection of thyroid cancer bone metastasis.
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KEYWORD
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Thyroid cancer, Bone metastasis, Bone scintigraphy, F-18 sodium fluoride, Positron emission tomography
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