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KMID : 0880420170180040585
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Korean Journal of Radiology
2017 Volume.18 No. 4 p.585 ~ p.596
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Influence of B1-Inhomogeneity on Pharmacokinetic Modeling of Dynamic Contrast-Enhanced MRI: A Simulation Study
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Park Bum-Woo
Choi Byung-Se
Sung Yu-Sub
Woo Dong-Cheol
Shim Woo-Hyun
Kim Kyung-Won
Choi Yoon-Seok
Pae Sang-Joon
Suh Ji-Yeon
Cho Hyung-Joon
Kim Jeong-Kon
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Abstract
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Objective: To simulate the B1-inhomogeneity-induced variation of pharmacokinetic parameters on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).
Materials and Methods: B1-inhomogeneity-induced flip angle (FA) variation was estimated in a phantom study. Monte Carlo simulation was performed to assess the FA-deviation-induced measurement error of the pre-contrast R1, contrast-enhancement ratio, Gd-concentration, and two-compartment pharmacokinetic parameters (Ktrans, ve, and vp).
Results: B1-inhomogeneity resulted in ?23?5% fluctuations (95% confidence interval [CI] of % error) of FA. The 95% CIs of FA-dependent % errors in the gray matter and blood were as follows: ?16.7?61.8% and ?16.7?61.8% for the pre-contrast R1, ?1.0?0.3% and ?5.2?1.3% for the contrast-enhancement ratio, and ?14.2?58.1% and ?14.1?57.8% for the Gd-concentration, respectively. These resulted in ?43.1?48.4% error for Ktrans, ?32.3?48.6% error for the ve, and ?43.2?48.6% error for vp. The pre-contrast R1 was more vulnerable to FA error than the contrast-enhancement ratio, and was therefore a significant cause of the Gd-concentration error. For example, a ?10% FA error led to a 23.6% deviation in the pre-contrast R1, ?0.4% in the contrast-enhancement ratio, and 23.6% in the Gd-concentration. In a simulated condition with a 3% FA error in a target lesion and a ?10% FA error in a feeding vessel, the % errors of the pharmacokinetic parameters were ?23.7% for Ktrans, ?23.7% for ve, and ?23.7% for vp.
Conclusion: Even a small degree of B1-inhomogeneity can cause a significant error in the measurement of pharmacokinetic parameters on DCE-MRI, while the vulnerability of the pre-contrast R1 calculations to FA deviations is a significant cause of the miscalculation.
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KEYWORD
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Brain, Magnetic resonance imaging, Dynamic contrast enhancement, Monte Carlo method, Phantoms, imaging
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