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KMID : 0880420170180040674
Korean Journal of Radiology
2017 Volume.18 No. 4 p.674 ~ p.681
The Blood Oxygenation T2* Values of Resectable Esophageal Squamous Cell Carcinomas as Measured by 3T Magnetic Resonance Imaging: Association with Tumor Stage
Tang Yu Lian

Zhang Xiao Ming
Yang Zhi Gang
Huang Yu Cheng
Chen Tian Wu
Chen Yan Li
Chen Fan
Zeng Nan Lin
Li Rui
Hu Jia Ni
Abstract
Objective: To explore the association between the blood oxygenation T2* values of resectable esophageal squamous cell carcinomas (ESCCs) and tumor stages.

Materials and Methods: This study included 48 ESCC patients and 20 healthy participants who had undergone esophageal T2*-weighted imaging to obtain T2* values of the tumors and normal esophagi. ESCC patients underwent surgical resections less than one week after imaging. Statistical analyses were performed to identify the association between T2* values of ESCCs and tumor stages.

Results: One-way ANOVA and Student-Newman-Keuls tests revealed that the T2* value could differentiate stage T1 ESCCs (17.7 ¡¾ 3.3 ms) from stage T2 and T3 tumors (24.6 ¡¾ 2.7 ms and 27.8 ¡¾ 5.6 ms, respectively; all ps < 0.001). Receiver operating curve (ROC) analysis showed the suitable cutoff T2* value of 21.3 ms for either differentiation. The former statistical tests demonstrated that the T2* value could not differentiate between stages T2 and T3 (24.6 ¡¾ 2.7 ms vs. 27.8 ¡¾ 5.6 ms, respectively, p > 0.05) or between N stages (N1 vs. N2 vs. N3: 24.7 ¡¾ 6.9 ms vs. 25.4 ¡¾ 4.5 ms vs. 26.8 ¡¾ 3.9 ms, respectively; all ps > 0.05). The former tests illustrated that the T2* value could differentiate anatomic stages I and II (18.8 ¡¾ 4.8 ms and 26.9 ¡¾ 5.9 ms, respectively) or stages I and III (27.3 ¡¾ 3.6 ms). ROC analysis depicted the same cutoff T2* value of 21.3 ms for either differentiation. In addition, the Student's t test revealed that the T2* value could determine grouped T stages (T0 vs. T1?3: 17.0 ¡¾ 2.9 ms vs. 25.2 ¡¾ 6.2 ms; T0?1 vs. T2?3: 17.3 ¡¾ 3.0 ms vs. 27.1 ¡¾ 5.3 ms; and T0?2 vs. T3: 18.8 ¡¾ 4.2 ms vs. 27.8 ¡¾ 5.6 ms, all ps < 0.001). ROC analysis indicated that the T2* value could detect ESCCs (cutoff, 20 ms), and discriminate between stages T0?1 and T2?3 (cutoff, 21.3 ms) and between T0?2 and T3 (cutoff, 20.4 ms).

Conclusion: The T2* value can be an additional quantitative indicator for detecting ESCC except for stage T1 cancer, and can preoperatively discriminate between some T stages and between anatomic stages of this tumor.
KEYWORD
Esophagus, Neoplasm, Carcinoma, Squamous cell, Magnetic resonance, Staging
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